Jul 3, 2026
A collaborative research group led by Drs. Oho (Jissen Women’s University) and Yokota (RAP Image Processing Research Team) has comprehensively analyzed gene co-expression in the brains of Huntington’s disease (HD) model mice using the team’s original TT method.
The researchers generated three-dimensional gene expression maps covering approximately 40,000 genes and, through comprehensive analysis, revealed diverse, disease-specific alterations in gene co-expression networks in the HD brain. Through topological modeling of gene co-expression networks, the researchers proposed hypotheses regarding key genes involved in the characteristic pathology of Huntington’s disease, providing new insights into disease mechanisms and potential therapeutic targets.
For more information, please see the RIKEN press release, “Comprehensive Analysis of Gene Co-expression in the Brains of Huntington’s Disease Model Mice,” published on July 3, 2026. The press release is written in Japanese only.
- Okamura-Oho, Y., Shimokawa, K., Oota, S. et al. Topological modeling of gene expression in the brain with Huntington’s disease reveals selective disruption of co-expression network. Sci Rep 16, 18328 (2026). doi: 10.1038/s41598-026-56101-8
